Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells

@article{Shinohara2006OsteopontinEI,
  title={Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells},
  author={Mari L Shinohara and Linrong Lu and Jing Bu and Miriam Bianchi de Frontin Werneck and Koichi Kobayashi and L. H. Glimcher and Harvey Cantor},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={498-506}
}
The observation that the T-bet transcription factor allows tissue-specific upregulation of intracellular osteopontin (Opn-i) in plasmacytoid dendritic cells (pDCs) suggests that Opn might contribute to the expression of interferon-α (IFN-α) in those cells. Here we show that Opn deficiency substantially reduced Toll-like receptor 9 (TLR9)–dependent IFN-α responses but spared expression of transcription factor NF-κB–dependent proinflammatory cytokines. Shortly after TLR9 engagement… CONTINUE READING