Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin.

@article{Schack2009OsteopontinEP,
  title={Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin.},
  author={Lotte Schack and Romualdas Stapulionis and Brian Christensen and Emil Kofod-Olsen and Uffe B Skov S\orensen and Thomas Vorup-Jensen and Esben Skipper S\orensen and Per H{\"o}llsberg},
  journal={Journal of immunology},
  year={2009},
  volume={182 11},
  pages={6943-50}
}
Osteopontin (OPN) is a cytokine with multiple functions, including immune defense mechanisms against invading microorganisms. OPN-deficient mice are impaired in clearing intracellular pathogens, suggesting an important role of OPN during phagocytosis, but it remains to be defined how OPN may enhance this innate immune process. Here, we demonstrate that OPN binds to monocytes, but not resting T cells, NK cells, or B cells, and mediates chemoattraction of IL-1-activated human monocytes. Moreover… CONTINUE READING

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