Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation.

Abstract

Intermittent PTH treatment increases cancellous bone mass in osteoporosis patients; however, it reveals diverse effects on cortical bone mass. Underlying molecular mechanisms for anabolic PTH actions are largely unknown. Because PTH regulates expression of osteopontin (OPN) in osteoblasts, OPN could be one of the targets of PTH in bone. Therefore, we… (More)

Topics

7 Figures and Tables

Cite this paper

@article{Kitahara2003OsteopontinDI, title={Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation.}, author={Keiichiro Kitahara and Muneaki Ishijima and Susan R. Rittling and Kunikazu Tsuji and Hisashi Kurosawa and Akira Nifuji and David T. Denhardt and Masaki Noda}, journal={Endocrinology}, year={2003}, volume={144 5}, pages={2132-40} }