Osteopontin deficiency and aging on nanomechanics of mouse bone.

  title={Osteopontin deficiency and aging on nanomechanics of mouse bone.},
  author={N Beril Kavukcuoglu and David T. Denhardt and Nejat Guzelsu and Adrian B. Mann},
  journal={Journal of biomedical materials research. Part A},
  volume={83 1},
Osteoporosis is a bone disease characterized by low bone mass and deterioration of the tissue leading to increased fragility. Osteopontin (OPN), a noncollageneous bone matrix protein, has been shown to play an important role in osteoporosis, bone resorption, and mineralization. However, OPN's role in bone mechanical properties on the submicron scale has not been studied in any detail. In this study, nanoindentation techniques were utilized to investigate how OPN and aging affect bone mechanical… CONTINUE READING