Osteopontin as two-sided mediator of intestinal inflammation

  title={Osteopontin as two-sided mediator of intestinal inflammation},
  author={Katja Heilmann and Ute Hoffmann and Ellen E. Witte and Christoph Loddenkemper and Christian Sina and Stefan Schreiber and Claudia Hayford and Pamela Holzlbhner and Kerstin Wolk and Elianne Tchatchou and Verena Moos and Martin Zeitz and Robert Sabat and Ursula Giinthert and Bianca Maria Wittig},
  booktitle={Journal of cellular and molecular medicine},
Osteopontin (OPN) is characterized as a major amplifier of Th1-immune responses. However, its role in intestinal inflammation is currently unknown. We found considerably raised OPN levels in blood of wild-type (WT) mice with dextran sodium sulfate (DSS)-induced colitis. To identify the role of this mediator in intestinal inflammation, we analysed experimental colitis in OPN-deficient (OPN(-/-)) mice. In the acute phase of colitis these mice showed more extensive colonic ulcerations and mucosal… CONTINUE READING
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Osteopontin, a 1173

  • J Agnholt, J Kelsen, L Schack, CL Hvas, JF Dahlerup, ES. Sorensen
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  • 2009

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