Osteopontin and splice variant expression level in human malignant glioma: radiobiologic effects and prognosis after radiotherapy.

Abstract

BACKGROUND AND PURPOSE We investigated the role of the hypoxia-associated secreted glycoprotein osteopontin (OPN) in the response of malignant glioma to radiotherapy by characterizing OPN and its splice variants in vitro and in patient material. MATERIAL AND METHODS The effect of siRNA knockdown of OPN splice variants on cellular and radiobiologic… (More)
DOI: 10.1016/j.radonc.2013.06.036

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