Osteopontin and related phosphorylated sialoproteins: effects on mineralization.

  title={Osteopontin and related phosphorylated sialoproteins: effects on mineralization.},
  author={Adele Ludin Boskey},
  journal={Annals of the New York Academy of Sciences},
Osteopontin is one of a family of phosphorylated sialoproteins found in the extracellular matrices of mineralized connective tissues. Solution studies from a variety of laboratories have shown that while some of these proteins (e.g., osteopontin, dentin sialoprotein) inhibit calcium phosphate production, others, such as bone sialoprotein, can act as a nucleator of calcium phosphate formation. The differences in the behaviors of these proteins can be related to their interactions with mineral… CONTINUE READING

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