Osteopontin adhesion receptors on gingival fibroblasts.

@article{DErrico1995OsteopontinAR,
  title={Osteopontin adhesion receptors on gingival fibroblasts.},
  author={J. D'Errico and J. Sauk and C. Prince and M. Somerman},
  journal={Journal of periodontal research},
  year={1995},
  volume={30 1},
  pages={
          34-41
        }
}
Osteopontin (OPN) promotes attachment and spreading of cells in an RGD dependent fashion, suggesting that OPN interacts with integrins on cell surfaces. Here in, we show that LM-609, a monoclonal antibody to the alpha v beta 3 integrin (a vitronectin receptor), inhibited OPN-mediated attachment of gingival fibroblasts. To characterize the cell surface receptors responsible for this interaction, we performed OPN-sepharose affinity chromatography using detergent extracts of 35S-methionine or 125I… Expand
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