Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity: evidence from cell lines down-regulated for OPN expression by a targeted ribozyme

Abstract

Osteopontin (OPN) is a GRGDS-containing phosphoglycoprotein that is capable of facilitating cell adhesion and modulating gene expression via integrin receptors. Three hammerhead ribozymes designed to target three different regions of OPN mRNA were shown to cleave the message catalyticallyin vitro. Plasmid vectors that had been engineered to express the… (More)
DOI: 10.1007/BF00118184

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@article{Feng1995OsteopontinM, title={Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity: evidence from cell lines down-regulated for OPN expression by a targeted ribozyme}, author={Bo Feng and Ellen E. Rollo and David T. Denhardt}, journal={Clinical & Experimental Metastasis}, year={1995}, volume={13}, pages={453-462} }