Osteopontin Is a Novel Downstream Target of SOX9 With Diagnostic Implications for Progression of Liver Fibrosis in Humans

@inproceedings{Pritchett2012OsteopontinIA,
  title={Osteopontin Is a Novel Downstream Target of SOX9 With Diagnostic Implications for Progression of Liver Fibrosis in Humans},
  author={James Pritchett and Emma L. Harvey and Varinder Athwal and Andrew A. Berry and Cliff Rowe and Fiona Oakley and Anna Moles and Derek Mann and Nicoletta Bobola and Andrew D Sharrocks and Brian Thomson and Abed Almuti Zaitoun and William Lucien Irving and I Neil Guha and Neil A Hanley and Karen Piper Hanley},
  booktitle={Hepatology},
  year={2012}
}
UNLABELLED Osteopontin (OPN) is an important component of the extracellular matrix (ECM), which promotes liver fibrosis and has been described as a biomarker for its severity. Previously, we have demonstrated that Sex-determining region Y-box 9 (SOX9) is ectopically expressed during activation of hepatic stellate cells (HSC) when it is responsible for the production of type 1 collagen, which causes scar formation in liver fibrosis. Here, we demonstrate that SOX9 regulates OPN. During normal… CONTINUE READING

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