Osteopontin: correlation with phagocytosis by brain macrophages in a rat model of stroke.

@article{Shin2011OsteopontinCW,
  title={Osteopontin: correlation with phagocytosis by brain macrophages in a rat model of stroke.},
  author={Yoo-Jin Shin and Hong Lim Kim and J Choi and Jung-Ho Cha and Mun-Yong Lee},
  journal={Glia},
  year={2011},
  volume={59 3},
  pages={413-23}
}
Osteopontin (OPN) is an adhesive glycoprotein linked to a variety of pathophysiological processes. We investigated whether OPN might act as an opsonin in the diseased brain by studying the postischemic expression and localization of OPN mRNA and protein in a rat model of ischemic stroke. In addition, we characterized the subcellular localization of OPN protein in the ischemic brain core. Induction of OPN mRNA occurred in activated microglia/macrophages in the ischemic core on days 3-7 after… CONTINUE READING
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