Osteopontin: an effector and an effect of tumor metastasis.

  title={Osteopontin: an effector and an effect of tumor metastasis.},
  author={Lalita A. Shevde and Samayita Das and David Wayne Clark and Rajeev S Samant},
  journal={Current molecular medicine},
  volume={10 1},
Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; this is also reflected by increased levels of OPN in the circulation. Thus, increased OPN levels the plasma are an effect of tumor growth and progression. Functionally, high OPN… CONTINUE READING

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