Osteopontin: a potential biomarker for heart failure and reverse remodeling after left ventricular assist device support.


BACKGROUND Left ventricular assist device (LVAD) support in end-stage heart failure (HF) leads to recovery of the patient's condition, size reduction of cardiomyocytes, and also volume reduction and change in the composition of the extracellular matrix (ECM). Myocardial expression of ECM osteopontin (OPN) protein increases with the severity of HF. We… (More)
DOI: 10.1016/j.healun.2011.03.015


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