Osteopontin: a new player in regulating hepatic ductular reaction and hepatic progenitor cell responses during chronic liver injury.

In recent years, an increasing number of reports have shown the involvement of osteopontin (OPN), a pleiotropic cytokine and an important component of the extracellular matrix (ECM), in the pathogenesis of liver injury and the development of fibrosis. 2 OPN is also frequently overexpressed in hepatocellular carcinoma (HCC), where it modulates HCC growth… CONTINUE READING