Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells.

@article{Nilsson2005OsteopontinAK,
  title={Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells.},
  author={Susan K Nilsson and Hayley M. Johnston and Genevieve A Whitty and Brenda M Williams and Ryan J Webb and David T. Denhardt and Ivan Bertoncello and Linda J Bendall and Paul J. Simmons and David N. Haylock},
  journal={Blood},
  year={2005},
  volume={106 4},
  pages={1232-9}
}
Although recent data suggests that osteoblasts play a key role within the hematopoietic stem cell (HSC) niche, the mechanisms underpinning this remain to be fully defined. The studies described herein examine the role in hematopoiesis of Osteopontin (Opn), a multidomain, phosphorylated glycoprotein, synthesized by osteoblasts, with well-described roles in cell adhesion, inflammatory responses, angiogenesis, and tumor metastasis. We demonstrate a previously unrecognized critical role for Opn in… CONTINUE READING
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