Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro.

@article{Feugier2005OsteopetroticMS,
  title={Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro.},
  author={Pierre Feugier and Na Li and Deog-Yeon Jo and Jae Hung Shieh and Karen L Mackenzie and J-F Lesesve and V{\'e}ronique Latger-Cannard and Dani{\`e}le Bensoussan and Ronald G. Crystal and Shahin Rafii and Jean François Stoltz and Malcolm A. S. Moore},
  journal={Stem cells and development},
  year={2005},
  volume={14 5},
  pages={505-16}
}
OP-9 cells are stromal cells derived from macrophage colony-stimulating factor (M-CSF)-deficient osteopetrotic mice. To evaluate the OP-9 capability to sustain long-term hematopoiesis, we reported the expansion of granulocyte colony-stimulating factor (G-CSF)-mobilized human peripheral blood (PB) CD34(+) cells in co-culture with murine OP-9 and MS-5 stromal cells, either transfected with various combinations of adenovectors (Ad) expressing c-kit ligand (KL) (either soluble or transmembrane form… CONTINUE READING
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