Osteopetrotic (op/op) mice have reduced microglia, no Aβ deposition, and no changes in dopaminergic neurons

Abstract

Activation of microglia is a part of the inflammatory response in neurodegenerative diseases but its role in the pathophysiology of these diseases is still unclear. The osteopetrotic (op/op) mouse lacks colony-stimulating factor-1 (CSF-1) and thus has a deficiency in microglia and macrophages. Prior reports have demonstrated that op/op mice deposit amyloid… (More)
DOI: 10.1186/1742-2094-4-31

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@article{Kondo2007OsteopetroticM, title={Osteopetrotic (op/op) mice have reduced microglia, no Aβ deposition, and no changes in dopaminergic neurons}, author={Yoichi Kondo and Cynthia A Lemere and Timothy J. Seabrook}, journal={Journal of Neuroinflammation}, year={2007}, volume={4}, pages={31 - 31} }