Osteopetrosis. Current clinical considerations.

  title={Osteopetrosis. Current clinical considerations.},
  author={Frederic Shapiro},
  journal={Clinical orthopaedics and related research},
Osteopetrosis is an inherited skeletal condition characterized by increased bone radiodensity. There are three clinical groups: infantile-malignant autosomal recessive, fatal within the first few years of life (in the absence of effective therapy); intermediate autosomal recessive, appears during the first decade of life but does not follow a malignant course; and autosomal dominant, with full-life expectancy but many orthopaedic problems. The infantile variant shows a myelophthisic anemia… CONTINUE READING
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