Osteonectin (SPARC) expression in human liver and in cultured human liver myofibroblasts.

  title={Osteonectin (SPARC) expression in human liver and in cultured human liver myofibroblasts.},
  author={Susanne Blazejewski and Brigitte le Bail and Liliane Boussarie and Jean Fr{\'e}d{\'e}ric Blanc and Luc Malaval and Kazuki Okubo and Jean Saric and Paulette Bioulac-Sage and Jean Rosenbaum},
  journal={The American journal of pathology},
  volume={151 3},
Osteonectin/SPARC is a glycoprotein involved in the regulation of cell shape, adhesion, migration, and proliferation. It also has complex effects on extracellular matrix synthesis and turnover. We found that osteonectin mRNA was very abundant in a human liver myofibroblast library. Using Northern and Western blot, immunoprecipitation, and radioimmunoassay, we found that cultured liver myofibroblasts actively secreted osteonectin. Myofibroblasts are very rare in normal liver but proliferate… CONTINUE READING
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