Osteonecrosis of the jaws (ONJ) in mice after extraction of teeth with periradicular disease.

  title={Osteonecrosis of the jaws (ONJ) in mice after extraction of teeth with periradicular disease.},
  author={Akrivoula Soundia and Danny Hadaya and Navid Esfandi and Rafael Scaf de Molon and Olga Bezouglaia and Sarah M. Dry and Flavia Q Pirih and Tara L. Aghaloo and Sotirios Tetradis},
Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as denosumab or bisphosphonates, prescribed to patients with bone malignancy or osteoporosis. The most common instigating local factor in ONJ pathogenesis is tooth extraction. However, in adults the great majority of teeth are extracted due to dental disease. Here, we have investigated alveolar bone healing after extraction of healthy teeth or teeth with naturally occurring periradicular disease in mice… CONTINUE READING


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