Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: a report from the Children's Cancer Group.

@article{Mattano2000OsteonecrosisAA,
  title={Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: a report from the Children's Cancer Group.},
  author={Leonard A. Mattano and Harland N. Sather and Michael e. Trigg and James B. Nachman},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2000},
  volume={18 18},
  pages={3262-72}
}
PURPOSE To determine the incidence, risk factors, and morbidity for osteonecrosis (ON) in children with acute lymphoblastic leukemia (ALL) treated with intensive chemotherapy including multiple, prolonged courses of corticosteroid. PATIENTS AND METHODS The occurrence of symptomatic ON was investigated retrospectively in 1, 409 children ages 1 to 20 years old receiving therapy for high-risk ALL on Children's Cancer Group (CCG) protocol CCG-1882. RESULTS ON was diagnosed in 111 patients (9.3… CONTINUE READING
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