Osteolytic and osteoblastic bone metastases: two extremes of the same spectrum?


Normal bone development and maintenance are sustained through a balanced communication between osteoclasts and osteoblasts. Invasion of the bone compartment by cancer cells causes an imbalance in their activities and results in predominantly bone lysing or bone forming phenotypes depending on the origin of the cancer. Tumor-induced bone lesions usually… (More)
DOI: 10.1007/978-3-642-21892-7_11


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