Osteolineage niche cells initiate hematopoietic stem cell mobilization.


Recent studies have implicated bone-lining osteoblasts as important regulators of hematopoietic stem cell (HSC) self-renewal and differentiation; however, because much of the evidence supporting this notion derives from indirect in vivo experiments, which are unavoidably complicated by the presence of other cell types within the complex bone marrow milieu… (More)
DOI: 10.1182/blood-2008-01-133710


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