Osteoinductivity of demineralized bone matrix in immunocompromised mice and rats is decreased by ovariectomy and restored by estrogen replacement.

@article{McMillan2007OsteoinductivityOD,
  title={Osteoinductivity of demineralized bone matrix in immunocompromised mice and rats is decreased by ovariectomy and restored by estrogen replacement.},
  author={Jacquelyn McMillan and Ramsey C. Kinney and Don M Ranly and S Fatehi-Sedeh and Zvi Schwartz and Barbara D Boyan},
  journal={Bone},
  year={2007},
  volume={40 1},
  pages={111-21}
}
The osteoinduction potential of human demineralized bone matrix (DBM) in females with low estrogen (E2) is unknown. Moreover, the osteoinductivity of commercial human DBM is tested in male athymic rats and mice, but DBM performance in these animals may not reflect performance in female animals or provide information on E2's role in the process. To gain insight, human DBM was implanted bilaterally in the gastrocnemius of twenty-four athymic female mice (10 mg/implant) and twenty-four athymic… CONTINUE READING