Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type

@article{Gugala2003OsteoinductionBE,
  title={Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type},
  author={Zbigniew Gugala and Elizabeth A. Olmsted-Davis and Francis H. Gannon and Ronald W. Lindsey and Alan R. Davis},
  journal={Gene Therapy},
  year={2003},
  volume={10},
  pages={1289-1296}
}
The objective of the study was to analyze and compare the abilities of various human cell types with inherently dissimilar osteogenic potentials to induce heterotopic bone formation following ex vivo transduction with two distinct adenoviral vectors encoding bone morphogenetic protein type 2 (BMP2). The cells comprised primary human bone marrow mesenchymal stem cells (BM-MSCs), primary human skin fibroblasts (SFs), and a human diploid fetal lung cell line (MRC-5). The vectors included… CONTINUE READING
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