Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening.

@article{Aelst2015OsteoglycinPC,
  title={Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening.},
  author={Lucas N.L. Van Aelst and Sandra Voss and Paolo Carai and Rick E.W. van Leeuwen and Davy Vanhoutte and Sandra Sanders-van Wijk and Luc W.M. Eurlings and Melissa Swinnen and Fons K C P Verheyen and Eric Verbeken and Holger M. Nef and Christian Troidl and Stuart A. Cook and Hans-Peter Brunner-la Rocca and Helge Moellmann and Anna-Pia Papageorgiou and Stephane R B Heymans},
  journal={Circulation research},
  year={2015},
  volume={116 3},
  pages={425-36}
}
RATIONALE To maintain cardiac mechanical and structural integrity after an ischemic insult, profound alterations occur within the extracellular matrix. Osteoglycin is a small leucine-rich proteoglycan previously described as a marker of cardiac hypertrophy. OBJECTIVE To establish whether osteoglycin may play a role in cardiac integrity and function after myocardial infarction (MI). METHODS AND RESULTS Osteoglycin expression is associated with collagen deposition and scar formation in mouse… CONTINUE READING
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