Osteogenic protein-1 promotes the synthesis and retention of extracellular matrix within bovine articular cartilage and chondrocyte cultures.

@article{Nishida2000OsteogenicPP,
  title={Osteogenic protein-1 promotes the synthesis and retention of extracellular matrix within bovine articular cartilage and chondrocyte cultures.},
  author={Yoshihiro Nishida and Cheryl B. Knudson and Klaus E. Kuettner and Warren Knudson},
  journal={Osteoarthritis and cartilage},
  year={2000},
  volume={8 2},
  pages={127-36}
}
OBJECTIVE We have used recombinant osteogenic protein-1 to investigate our hypothesis that proper repair and maintenance of cartilage requires not only enhanced biosynthesis and replenishment of the extracellular matrix but also the enhancement of components necessary for matrix retention. DESIGN The effects of osteogenic protein-1 were examined on bovine articular cartilage slices as well as isolated chondrocytes grown in alginate beads. Cartilage slices were examined for accumulation of… CONTINUE READING

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