Osteogenic induction protects rat bone marrow-derived mesenchymal stem cells against hypoxia-induced apoptosis in vitro.

@article{Gao2013OsteogenicIP,
  title={Osteogenic induction protects rat bone marrow-derived mesenchymal stem cells against hypoxia-induced apoptosis in vitro.},
  author={You-Shui Gao and Hao Ding and Xuetao Xie and Chang-Qing Zhang},
  journal={The Journal of surgical research},
  year={2013},
  volume={184 2},
  pages={
          873-9
        }
}
BACKGROUND Bone marrow-derived mesenchymal stem cells (BMSCs) undergo hypoxia-induced apoptosis when cells are transplanted from a normoxic to a hypoxic microenvironment in vivo. The effect of the osteogenic microenvironment on BMSCs under hypoxic conditions has not yet been revealed. MATERIALS AND METHODS In the current study, we investigated the effects on BMSCs of hypoxia and osteogenic induction (OI) individually and in combination. We isolated BMSCs from rat bone marrow and confirmed… CONTINUE READING
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