Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells.

@article{Aslan2006OsteogenicDO,
  title={Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells.},
  author={Hadi Aslan and Yoram Zilberman and Leonid Ari Kandel and Meir Liebergall and Rod J. Oskouian and Dan Gazit and Zulma Gazit},
  journal={Stem cells},
  year={2006},
  volume={24 7},
  pages={1728-37}
}
The culture expansion of human mesenchymal stem cells (hMSCs) may alter their characteristics and is a costly and time-consuming stage. This study demonstrates for the first time that immunoisolated noncultured CD105-positive (CD105(+)) hMSCs are multipotent in vitro and exhibit the capacity to form bone in vivo. hMSCs are recognized as promising tools for bone regeneration. However, the culture stage is a limiting step in the clinical setting. To establish a simple, efficient, and fast method… CONTINUE READING
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