Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum

@inproceedings{Castrn2015OsteogenicDO,
  title={Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum},
  author={Eeva Castr{\'e}n and Tarvo Sillat and S Oja and Ariel Noro and Anita Laitinen and Yrj{\"o} T. Konttinen and Petri Lehenkari and Mika V J Hukkanen and Matti Korhonen},
  booktitle={Stem Cell Research & Therapy},
  year={2015}
}
Bone marrow-derived mesenchymal stromal cells (MSCs) have been intensely studied for the purpose of developing solutions for clinical tissue engineering. Autologous MSCs can potentially be used to replace tissue defects, but the procedure also carries risks such as immunization and xenogeneic infection. Replacement of the commonly used fetal calf serum (FCS) with human platelet lysate and plasma (PLP) to support cell growth may reduce some of these risks. Altered media could, however, influence… CONTINUE READING

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