Osteogenic differentiation of human mesenchymal bone marrow cells in silk scaffolds is regulated by nitric oxide.

@article{Damoulis2007OsteogenicDO,
  title={Osteogenic differentiation of human mesenchymal bone marrow cells in silk scaffolds is regulated by nitric oxide.},
  author={Petros D. Damoulis and Dimitrios E Drakos and Eleni Gagari and David L Kaplan},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1117},
  pages={
          367-76
        }
}
Bone marrow-derived mesenchymal stem cells (BMSC) are a powerful tool for tissue engineering and can be used in the regeneration of bone and other tissues. Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) plays an important role in bone development and healing. We hypothesized that NO plays a role in osteogenic differentiation of BMSC cultured in three-dimensional silk scaffolds. eNOS protein was measured by Western Analysis and its activity was assessed by measuring nitrite in… CONTINUE READING
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