Osteogenic differentiation of human mesenchymal stem cells directed by extracellular matrix-mimicking ligands in a biomimetic self-assembled peptide amphiphile nanomatrix.

@article{Anderson2009OsteogenicDO,
  title={Osteogenic differentiation of human mesenchymal stem cells directed by extracellular matrix-mimicking ligands in a biomimetic self-assembled peptide amphiphile nanomatrix.},
  author={Joel M Anderson and Meenakshi Kushwaha and Ajay Tambralli and Susan L Bellis and Renato P. Camata and Ho-wook Jun},
  journal={Biomacromolecules},
  year={2009},
  volume={10 10},
  pages={
          2935-44
        }
}
This study investigated the ability of nanoscale, biomimetic peptide amphiphile (PA) scaffolds inscribed with specific cellular adhesive ligands to direct the osteogenic differentiation of human mesenchymal stem cells (hMSCs) without osteogenic supplements. PA sequences were synthesized to mimic the native bone extracellular matrix (ECM), expressing different isolated ligands (i.e., RGDS, DGEA, KRSR). All PAs were presented as self-assembled two-dimensional coatings for the seeded hMSCs… CONTINUE READING
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