Osteogenic differentiation of bone marrow mesenchymal stem cells by adenovirus-mediated expression of leptin.

@article{Han2010OsteogenicDO,
  title={Osteogenic differentiation of bone marrow mesenchymal stem cells by adenovirus-mediated expression of leptin.},
  author={Guosheng Han and Yingying Jing and Yuhui Zhang and Zhijian Yue and Xiaowu Hu and Laixing Wang and Jinchuan Liang and J Liu},
  journal={Regulatory peptides},
  year={2010},
  volume={163 1-3},
  pages={107-12}
}
Previous studies demonstrate that leptin has an osteogenic differentiation effect on bone marrow mesenchymal stem cells (MSCs). However, the effect of adenovirus-mediated leptin on MSCs differentiation has not been reported. To explore the mechanism, we constructed a recombinant adenoviral vector Ad-leptin and transfected propagated MSCs in vitro. The effects of Ad-leptin on MSCs growth and osteogenic differentiation were examined. The results showed that Ad-leptin inhibited the transfected… CONTINUE READING

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