Osteogenesis in rats induced by a novel recombinant helper-dependent bone morphogenetic protein-9 (BMP-9) adenovirus.

@article{Li2003OsteogenesisIR,
  title={Osteogenesis in rats induced by a novel recombinant helper-dependent bone morphogenetic protein-9 (BMP-9) adenovirus.},
  author={Jin Zhong Li and Gerald R. Hankins and Chinghai Kao and Hongwei Li and John Kammauff and Gregory A. Helm},
  journal={The journal of gene medicine},
  year={2003},
  volume={5 9},
  pages={748-56}
}
BACKGROUND Although recombinant first-generation BMP adenoviruses can induce ectopic bone formation in immune deficient animals, the osteoinductive activity of these BMP vectors is reduced in immune competent animals. Helper-dependent adenoviral vectors have been developed to decrease the immune response and, therefore, increase gene expression in immune competent animals compared with first-generation vectors. In the present study, the osteoinductive activity of a helper-dependent GFP and BMP… CONTINUE READING

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