Osteogenesis imperfecta type VI: a form of brittle bone disease with a mineralization defect.

@article{Glorieux2002OsteogenesisIT,
  title={Osteogenesis imperfecta type VI: a form of brittle bone disease with a mineralization defect.},
  author={Francis H Glorieux and Leanne Marie Ward and Frank Rauch and Ljiljana Lalic and Peter J. Roughley and Rose Travers},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2002},
  volume={17 1},
  pages={30-8}
}
Osteogenesis imperfecta (OI) is a heritable disease of bone in which the hallmark is bone fragility. Usually, the disorder is divided into four groups on clinical grounds. We previously described a group of patients initially classified with OI type IV who had a discrete phenotype including hyperplastic callus formation without evidence of mutations in type I collagen. We called that disease entity OI type V. In this study, we describe another group of 8 patients initially diagnosed with OI… CONTINUE READING