Osteogenesis imperfecta at the beginning of bone and joint decade.

  title={Osteogenesis imperfecta at the beginning of bone and joint decade.},
  author={Dragan Primorac and David W. Rowe and Monica Mottes and Ingeborg Bari{\vs}i{\'c} and Darko Anti{\vc}evi{\'c} and S Mirandola and Macarena Gomez Lira and Ivo Kalajzic and Vesna Ku{\vs}ec and Francis H Glorieux},
  journal={Croatian medical journal},
  volume={42 4},
Osteogenesis imperfecta (OI), or brittle bone disease, is a heritable disorder characterized by increased bone fragility. Four different types of the disease are commonly distinguished, ranging from a mild condition (type I) to a lethal one (type II). Types III and IV are the severe forms surviving the neonatal period. In most cases, there is a reduction in the production of normal type I collagen or the synthesis of abnormal collagen as a result of mutations in the type I collagen genes. These… CONTINUE READING