Osteogenesis imperfecta: changes in noncollagenous proteins in bone.

@article{Vetter1991OsteogenesisIC,
  title={Osteogenesis imperfecta: changes in noncollagenous proteins in bone.},
  author={Ulrich Vetter and Larry Warren Fisher and Keith P. Mintz and Jeffrey B Kopp and Noreen Tuross and John D. Termine and Pamela G Robey},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1991},
  volume={6 5},
  pages={
          501-5
        }
}
The noncollagenous proteins osteonectin, bone sialoprotein, osteocalcin, the small proteoglycan decorin (PG II), and alpha 2-HS glycoprotein (which is synthesized in the liver but highly concentrated in bone) were measured in extracts of cortical bone from 3 type I, 2 type II, 8 type III and 13 type IV patients with osteogenesis imperfecta (OI) and from 7 control subjects. Osteonectin was found to be reduced in the bone of all OI patients. The bone from severely affected type III OI patients… CONTINUE READING

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