Osteofibrous Dysplasia and Adamantinoma in Children and Adolescents: A Clinicopathologic Reappraisal

@article{Gleason2008OsteofibrousDA,
  title={Osteofibrous Dysplasia and Adamantinoma in Children and Adolescents: A Clinicopathologic Reappraisal},
  author={Briana C. Gleason and Bernadette Liegl-Atzwanger and Harry P. W. Kozakewich and Susan A. Connolly and Mark C. Gebhardt and Jonathan A. Fletcher and Antonio R. Perez-Atayde},
  journal={The American Journal of Surgical Pathology},
  year={2008},
  volume={32},
  pages={363-376}
}
Osteofibrous dysplasia (OFD) and adamantinoma are rare and most commonly arise in the tibia of young individuals. Although OFD has typical histopathologic features, areas resembling OFD have often been noted at the periphery of otherwise classic adamantinomas, and some have suggested that OFD may be either a precursor to or a regressive phase of adamantinoma. The so-called OFD-like adamantinoma encompasses some features of both OFD and adamantinoma. We studied the clinical, imaging… Expand

Paper Mentions

Observational Clinical Trial
The aim of the present study is to obtain long term follow-up in patients with osteofibrous dysplasia, to assess natural history of the disease, late results of treatment and in… Expand
ConditionsOsteofibrous Dysplasia
InterventionBehavioral
Osteofibrous Dysplasia and Adamantinoma
TLDR
Osteofibrous dysplasia is a rare, benign, fibro‐osseous lesion that typically is seen within the cortex of the tibia in children and controversy exists as to whether OFD is a precursor lesion to AD or whether OfD may be a residual lesion resulting from a spontaneously regressing AD. Expand
p63 expression in adamantinoma
TLDR
The presence of staining for p63, albeit rare, in oste ofibrous dysplasia supports the notion of a possible relationship between osteofibrous Dysplasia and adamantinoma and suggests that, in some situations, p63 may be useful in helping differentiate metastatic carcinoma from adamantinomas. Expand
Osteofibrous Dysplasia-like Adamantinoma of the Tibia in a 15-Year-Old Girl.
TLDR
A rare case of an osteofibrous dysplasia-like adamantinoma of the tibia in a 15-year-old girl who showed no progression over 2 years is reported, highlighting the rarity of this intermediate form and its potential to remain stable. Expand
Adamantinoma of the Femur With High-Grade Epithelial and Sarcomatoid Components: Case Report and Review of the Literature
Adamantinomas are rare low-grade malignant bone tumors that are composed of epithelial cells set in an osteofibrous stroma. Osteofibrous dysplasia-like and classic forms are well known; however,Expand
A Rare Case of Adamantinoma in an 11-Year-Old
Adamantinoma is a low-grade malignant lesion most frequently arising in the tibial cortex. Approximately 27% of adamantinomas present with multifocal lesions in the same bone and 10% of cases involveExpand
Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma.
TLDR
It is important that all radiologists are aware of the nature and imaging characteristics of these tumour sub-types, so that suspected lesions are recognized and appropriately referred to specialist bone tumour services for work-up and management. Expand
Does osteofibrous dysplasia progress to adamantinoma and how should they be treated?
TLDR
No evidence of progression from OFD to adamantinoma is found and Conservative management with observation or curettage is often successful for patients with OFD and OFD‐like adamantinomas. Expand
Long-term outcome following treatment of Adamantinoma and Osteofibrous dysplasia of long bones.
TLDR
The overall prognosis of AD and OFD is good, yet local recurrence rates are high, irrespective of surgical strategy, and a more radical surgical approach should be considered, especially when treating AD. Expand
Genetic and molecular reappraisal of spindle cell adamantinoma of bone reveals a small subset of misclassified intraosseous synovial sarcoma
TLDR
The morphologic and immunophenotypic overlap between spindle cell adamantinoma and intraosseous synovial sarcoma of the tibia is highlighted and investigation of SS18 status to exclude synovials is suggested. Expand
Osteosarcoma arising in a case of osteofibrous dysplasia of tibia with classic adamantinoma: A case report and literature review
TLDR
This case is remarkable as the patient was only 14 years old and the tumour showed typical features of osteosarcoma, with feature of osteofibrous dysplasia and adamantinoma found in the same specimen. Expand
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TLDR
The present case and the literature review suggest that an OFD-like adamantinoma may be a precursor lesion of classic adamantinomas, particularly when the destructive changes are seen radiologically. Expand
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TLDR
Five cases of osteofibrous dysplasia-like adamantinoma of the tibia in young patients ranging from ages 4 1/2 to 14 years are described, and in the fibroblastic stroma of the tumors, spindle epithel cells that were indistinguishable from the epithelial cells of oste ofibrous Dysplasia, suggesting that there is an overlap between these conditions. Expand
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TLDR
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TLDR
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TLDR
It is suggested that many patients with a diagnosis of fibrous dysplasia or osteofibrous Dysplasia of the tibia actually have an adamantinoma, and that osteofIBrous dys plasia is often a locally aggressive lesion that progresses until it is widely resected. Expand
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TLDR
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