Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow.

@article{Lu2012OsteocyticNI,
  title={Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow.},
  author={Xiangshun Lu and Bo Huo and Victor Chiang and X. Edward Guo},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2012},
  volume={27 3},
  pages={
          563-74
        }
}
Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation by activating biochemical pathways and mediating the cellular activities of other bone cells. Little is known about how osteocytic networks respond to physiological mechanical stimuli. In this study, we compared the mechanical sensitivity of osteocytic and osteoblastic networks under physiological-related fluid shear stress (0.5 to 4 Pa). The intracellular calcium ([Ca(2+)](i)) responses in micropatterned… CONTINUE READING

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