Osteocyte primary cilium and its role in bone mechanotransduction.

  title={Osteocyte primary cilium and its role in bone mechanotransduction.},
  author={Sara Temiyasathit and Christopher Rae Jacobs},
  journal={Annals of the New York Academy of Sciences},
Bone is a dynamic tissue that adapts to its local loading environment. Mechanotransduction, the process by which cells convert mechanical forces into biochemical signals, is important for maintaining bone health and homeostasis. It is less clear, however, what the cellular mechanosensor(s) are that sense and initiate these signaling cascades. Primary cilia are solitary rigid structures that extend from the cell body into the extracellular space and as a consequence are prime candidates for… CONTINUE READING

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