Osteocyte function, osteocyte death and bone fracture resistance.

  title={Osteocyte function, osteocyte death and bone fracture resistance.},
  author={Brendon S. Noble and Jonathan Reeve},
  journal={Molecular and cellular endocrinology},
  volume={159 1-2},
The function of the most numerous cell in bone, the osteocyte, has until recently been mysterious and at times controversial. There is now an emerging consensus that osteocytes modulate signals arising from mechanical loading and so direct the appearance and disappearance of bone tissue at the microscopic level, which allows bone as an organ both to grow and to adapt efficiently to the body's mechanical needs for strength with lightness. Osteocytes appear to use some molecular signalling… CONTINUE READING


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