Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.

@article{Dijke2008OsteocytederivedSI,
  title={Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.},
  author={Peter Ten Dijke and Carola Krause and David J. J. de Gorter and Clemens W G M L{\"o}wik and R L Van bezooijen},
  journal={The Journal of bone and joint surgery. American volume},
  year={2008},
  volume={90 Suppl 1},
  pages={31-5}
}
Sclerosteosis and Van Buchem disease are rare, high-bone-mass disorders that have been linked to deficiency in the SOST gene, encoding sclerostin. Sclerostin belongs to the DAN family of glycoproteins, of which multiple family members have been shown to antagonize bone morphogenetic protein (BMP) and/or Wnt activity. Sclerostin is specifically expressed by osteocytes and inhibits BMP-induced osteoblast differentiation and ectopic bone formation. Sclerostin binds only weakly to BMPs and does not… CONTINUE READING

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