Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.

  title={Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.},
  author={David G. Winkler and May S Kung Sutherland and James C. Geoghegan and Changpu Yu and Trenton Hayes and John E Skonier and Diana Shpektor and Mechtild Jonas and Brian R Kovacevich and Karen Staehling-Hampton and Mark Appleby and Mary E. Brunkow and John A Latham},
  journal={The EMBO journal},
  volume={22 23},
There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic bone disorders provide insight into bone regulatory processes. Sclerosteosis is a disease typified by high bone mass due to the loss of SOST expression. Sclerostin, the SOST gene protein product, competed with the type I and type II bone morphogenetic protein (BMP) receptors for binding to BMPs, decreased BMP signaling and suppressed mineralization of osteoblastic cells. SOST expression was detected in… CONTINUE READING
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