Osteocyte Alterations Induce Osteoclastogenesis in an In Vitro Model of Gaucher Disease


Gaucher disease (GD) is caused by mutations in the glucosylceramidase β (GBA 1) gene that confer a deficient level of activity of glucocerebrosidase (GCase). This deficiency leads to the accumulation of the glycolipid glucocerebroside in the lysosomes of cells, mainly in the monocyte/macrophage lineage. Its mildest form is Type I GD, characterized by non… (More)
DOI: 10.3390/ijms18010112


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