Osteoclasts in arthritis and Th17 cell development.

@article{Okamoto2011OsteoclastsIA,
  title={Osteoclasts in arthritis and Th17 cell development.},
  author={Kazuo Okamoto and Hiroshi Takayanagi},
  journal={International immunopharmacology},
  year={2011},
  volume={11 5},
  pages={543-8}
}
Bone destruction associated with rheumatoid arthritis (RA) is mainly attributed to the abnormal activation of osteoclasts, which are terminally differentiated cells of monocyte/macrophage lineage that resorb bone matrix. Studies on the immune regulation of osteoclasts in RA have promoted the new research field of "osteoimmunology", which investigates the interplay of the skeletal and immune systems at the molecular level. This interdisciplinary field is proving to be crucial to advances in the… CONTINUE READING
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