Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study.

Abstract

Bone resorption is controlled by the local production of soluble regulatory molecules within the marrow microenvironment that mediate osteoclast recruitment, differentiation, and activation. Under normal conditions osteoclasts are rarely seen; in many pathologic states, however, the number of osteoclasts is dramatically increased, resulting in a net-loss of… (More)

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