Osteoclasts and transforming growth factor-beta: estrogen-mediated isoform-specific regulation of production.

@article{Robinson1996OsteoclastsAT,
  title={Osteoclasts and transforming growth factor-beta: estrogen-mediated isoform-specific regulation of production.},
  author={Jodie A Robinson and B. Lawrence Riggs and Thomas C. Spelsberg and Merry Jo Oursler},
  journal={Endocrinology},
  year={1996},
  volume={137 2},
  pages={615-21}
}
Estrogen deficiency induced by menopause leads to an increase in bone resorption that is not compensated for by a comparable increase in bone formation, resulting in excessive bone loss. Clinically, estrogen replacement reverses these processes, but the mechanisms by which this takes place are not completely understood. Both osteoclasts and osteoblasts contain functional estrogen receptors and, therefore, may be directly involved in these responses. Because both osteoclasts and osteoblasts… CONTINUE READING
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Human giant cell tumors of the bon;-fosteoclastomasj are estrogen tarzet cells

  • MJ Oursler, L Pederson, L Fitzpatrick, BL Riggs, TC Spelsberg
  • Proc Nat1 Acad Sci USA
  • 1992
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