Osteoclasts: New Insights

@article{Xu2013OsteoclastsNI,
  title={Osteoclasts: New Insights},
  author={Feng Xu and Steven L Teitelbaum},
  journal={Bone Research},
  year={2013},
  volume={1},
  pages={11-26}
}
Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders. Osteoclasts differentiate from cells of the monocyte/macrophage lineage upon stimulation of two essential factors, the monocyte/macrophage colony stimulating factor (M-CSF) and receptor activation of NF-κB ligand (RANKL). M-CSF binds to its receptor c-Fms to activate distinct signaling pathways to stimulate the… CONTINUE READING

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