Osteoclastic acidification pathways during bone resorption.

@article{Rousselle2002OsteoclasticAP,
  title={Osteoclastic acidification pathways during bone resorption.},
  author={A-V Rousselle and Dominique Heymann},
  journal={Bone},
  year={2002},
  volume={30 4},
  pages={
          533-40
        }
}
Osteoclasts resorb bone by attaching to the surface and then secreting protons into an extracellular compartment formed between osteoclast and bone surface. This secretion is necessary for bone mineral solubilization and the digestion of organic bone matrix by acid proteases. This study summarizes the characterization and role of each type of ion transport and defines the main biochemical mechanisms involved in the dissolution of bone mineral during bone resorption. The primary mechanism… CONTINUE READING
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