Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

Abstract

Osteoclasts are multinucleated haematopoietic cells that resorb bone. Increased osteoclast activity causes osteoporosis, a disorder resulting in a low bone mass and a high risk of fractures. Increased osteoclast size and numbers are also a hallmark of other disorders, such as Paget’s disease and multiple myeloma. The protein c-Fos, a component of the AP-1… (More)
DOI: 10.1038/nature07019

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